Importantly, a role for P2Y1 on microglia activation has been repeatedly demonstrated previously (Davalos et al., 2005; Farber and Kettenmann, 2006; De Simone et al., 2010) with studies showing P2Y1-mediated signaling on microglia to affect neurodegeneration during ischemia and traumatic brain injury (Shinozaki et al., 2017; Fukumoto et al., 2018). The gene discussed is P2RY1; the disease is ischemia.