Indirect evidence suggesting a functional role for P2Y1 and P2Y4, P2Y receptors undergoing the strongest increase in their expression following status epilepticus, stems from a study showing that treatment with ADP, main endogenous P2Y1 agonist, increases seizure severity during status epilepticus and treatment with UTP, main endogenous agonists of P2Y4, decrease seizure severity (Alves et al., 2017). Here, P2RY4 is linked to status epilepticus.