In line with anti-convulsive effects of P2Y1 antagonism being mediated via inflammation, mice pre-treated with minocycline and injected with the P2Y1 antagonist MRS25 showed no seizure reduction when compared to vehicle-injected mice subjected to intraamygdala KA status epilepticus and pre-treated with minocycline (Figure 3C). This evidence concerns the gene P2RY1 and status epilepticus.