Acacetin also blocked the phosphorylations of Stat-1 (Tyr701) and Stat-3 (Tyr705), as well as restrained the expression levels of pro-angiogenic factors, e.g. VEGF, eNOS, iNOS, MMP-2 and bFGF, in cancer cells (Bhat et al., 2013). The gene discussed is MMP2; the disease is cancer.