Furthermore, Cx43 also plays a relevant role in neurodegenerative diseases such as AD, Parkinson ́s disease, ALS, Multiple sclerosis (Xing, 2019) and neuropsychiatric diseases, including major depressive disorder (Kim, 2018), highlighting the deleterious effect of compromising Cx43 functions in astrocytes. This evidence concerns the gene GJA1 and neurodegenerative disease.