IL6 and major depressive disorder: Moreover, the elevated plasma concentrations of CRP and IL-6 in patients with major depressive disorder are reported to be positively related to the increased plasma nesfatin-1 level (Xia et al., 2018), which is an anorexigenic molecule localized widely in the brain and peripheral tissues with multiple biological activities including regulation of feeding and mood (Weibert et al., 2019).