Taking together with their important role in linking neuropsychiatric behaviors to synaptic plasticity (Jangra et al., 2014; Reinhard et al., 2016), these results indicated that BDNF-related imbalance expression of Copine-6 and synapse plasticity-associated proteins play a vital role in the depression-like behavior induced by LPS challenge. Here, CPNE6 is linked to major depressive disorder.