MTOR and neoplasm: Research shows that the PI3K/Akt activation of the mTOR signaling pathway can inhibit the apoptosis of cells, and the activation of PI3K can cause mutations in the normal Akt physiological function of the cells, and generate induced tumors, to suppresses tumor cell apoptosis (Guertin and Sabatini, 2005; Banumathy and Cairns, 2010).