Several proteins linked to AD and involved in the synaptic vesicle cycle were found to display loss of rhythmicity in the hippocampus during aging, including amphiphysin, AP-2 complex subunits, clathrin heavy chain, endophilin-A1, synaptogyrin-3, and syntaxin-binding protein 1 (Figures 4, 5 and Supplementary Table 1). The gene discussed is CLTC; the disease is Alzheimer disease.