Recently, the National Institute on Aging-Alzheimer’s Association (NIA-AA) has considered that amyloid (A) and tau (T) biomarkers indicate specific neuropathologic changes of AD, and proposed a new biological definition: individuals with biomarker profile “A+T+” (both abnormal A and T biomarkers) would be defined as AD (Jack et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.