Innate immune activation, in response to the pattern recognition receptors’ recognition to the misfolded or aberrant proteins (Aβ in case of AD) (Barger and Harmon, 1997; Meda et al., 1999), results in the activation of NLRP3 components in the inflammasome formation (Schnaars et al., 2013; Nakanishi et al., 2018; Yin et al., 2018). The gene discussed is NLRP3; the disease is Alzheimer disease.