DOCK4 and autism: To understand the function of the two dyslexia/autism-linked DOCK4 variations, we studied the mutant generated by the IMMP2L_DOCK4 fusion transcript, Dock4-945VS (1–945 aa of Dock4 + Val + Ser), and the missense mutant of rs20741307 variation, Dock4-R853H (Arg853His), by examining their molecular and cellular functions through several assays.