Regarding Tau protein levels, a high increase in the levels of total Tau (Tau-5 antibody) was found in the cortex of HD patients and this is accompanied with the appearance of lower molecular weight (35 and 39 KD) bands (Fernández-Nogales et al., 2014), while no changes were found in the striatum (Fernández-Nogales et al., 2014). Here, MAPT is linked to Huntington disease.