There is growing evidence that HD inclusions, in addition to mHtt, can nucleate other proteins like those that are characteristic of other neurodegenerative diseases, like α-synuclein -found in Parkinson’s disease (Corrochano et al., 2012; Herrera and Outeiro, 2012; Tomas-Zapico et al., 2012), TDP-43 -found in amyotrophic lateral sclerosis- (Schwab et al., 2008; Coudert et al., 2019), or Tau -found in Tauopathies such as Alzheimer’s disease (Fernández-Nogales et al., 2014; Vuono et al., 2015; St-Amour et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.