MAPT and supranuclear palsy, progressive, 1: As previously commented, in some Tauopathies including PSP, CB, Pick’s disease (PiD) and FTLD with Tau+ inclusions (FTLD-Tau), alteration of alternative splicing of exon 10 produces an imbalance in 4R-Tau and 3R-Tau isoforms (Park et al., 2016).