Deregulation of Tau phosphorylation is deleterious for neurons and has been implicated in many diseases such as AD, where Tau hyperphosphorylation favors its detachment from the microtubules thus increasing the levels of soluble Tau available for self-aggregation leading to the formation of neurofibrillary tangles (NFT) and/or neuropil threads (NT; Wang and Mandelkow, 2016). The gene discussed is MAPT; the disease is Alzheimer disease.