SRSF6 and Huntington disease: In this regard, it has been shown an increase in the levels of phosphorylation of SRSF6 in the striatum and cortex of HD patients and R6/1 mice (Fernández-Nogales et al., 2014) which may favor dissociation from nuclear speckles (Yin et al., 2012; Naro and Sette, 2013).