These observations were consistent with the data obtained during the EPM test (Figure 3C), which is also widely used as an indicator of anxiety-related behavior (Bailey and Crawley, 2009) and which further propose the possibility that Pdpn might serve a physiological role in the prevention of the expression of anxiety-related behaviors that might occur in concomitance with altered neurogenesis. The gene discussed is PDPN; the disease is Anxiety.