Yet, most of the available studies about Pdpn in the brain have focused on its involvement in the promotion of brain tumors (Astarita et al., 2012; Peterziel et al., 2012; Grau et al., 2015; Kolar et al., 2015) and the intrinsic role of Pdpn in neurogenesis and memory-related synaptic plasticity in the adult brain remained undetermined. The gene discussed is PDPN; the disease is brain neoplasm.