CFLAR and neoplasm: At higher levels of receptor engagement, the caspase‐8:FLIP(L) ratio will increase as total cellular levels of FLIP(L) are typically lower level than procaspase‐8 (even when its expression is elevated in tumour cells) 22 and the heterodimer will then catalyse the processing of adjacent homodimers, thereby accelerating procaspase‐8 activation and apoptosis induction.