CD4 and myeloid sarcoma: Besides Th1 cells and Th17 cells, Th1* cells (expressing both T-bet and RORγt, and CXCR3 and CCR6 [13]) are found in the CSF during early disease, in post-mortem MS brain tissues [9, 12, 14] and in autoproliferating T cells, which are enriched for brain-homing CD4+ T cells [15].