Indeed, in vitro administration of apocynin showed a reduction in cytokines IL-6, IFN-β, CXCL10, and CCL5, likely as a consequence of the increased expression of the inflammatory cytokine modulators SOCS1 and SOCS3, in low, moderate, and high pathogenic strains of influenza (183). This evidence concerns the gene IFNB1 and influenza.