The results of our study suggest that (1) the perfusion of the microvasculature within peritoneal metastases of EOC is poor, (2) HIF-1α and VEGF expression are present in peritoneal metastases, (3) the microvascular networks of the peritoneum and EOC metastases are continuous through all peritoneal layers and (4) the intra-abdominal presence of EOC and/or PC does not affect the microvasculature in other unaffected regions of the peritoneum. Here, HIF1A is linked to pachyonychia congenita.