A strongly enhanced sensitivity of MYC-driven cells to a perturbation of the splicing machinery has been observed before in different biological systems; specifically, upregulation of the core spliceosome machinery is an essential step in MYC-driven lymphomagenesis, and MYC-driven lymphomas depend on PRMT5, an arginine methyltransferase that methylates spliceosomal proteins (Koh et al., 2015). Here, PRMT5 is linked to lymphoma.