While some software-based insulin dosing calculators represent an improvement over paper-based protocols with regards to severe hypoglycemia and time in range [17, 18], most are still are not capable of eliminating the risk for long-lasting and deep hypoglycemia, minimizing the time spent in moderate hypoglycemia (2.22–3.89 mmol/L), while simultaneously improving upon other glucose metrics associated with ICU mortality rates such as time spent in control range 3.89–7.78 mmol/L and glucose variability [19, 20]. This evidence concerns the gene INS and Hypoglycemia.