Sixteen genes (ADAM19, ARMS2, BTBD16, CFH, CFHR1, CFHR3, GPR108, PILRA, PILRB, PLA2G12A, PLEKHA1, PMS2P1, PPIL3, RDH5, STAG3L5P, and TNFRSF10A) were associated with AMD disease status in over 10 tissues, pointing to effects likely acting in systemic processes. Here, RDH5 is linked to age-related macular degeneration.