Sixteen genes (ADAM19, ARMS2, BTBD16, CFH, CFHR1, CFHR3, GPR108, PILRA, PILRB, PLA2G12A, PLEKHA1, PMS2P1, PPIL3, RDH5, STAG3L5P, and TNFRSF10A) were associated with AMD disease status in over 10 tissues, pointing to effects likely acting in systemic processes. This evidence concerns the gene PILRB and age-related macular degeneration.