CR2 and age-related macular degeneration: Our study also identified two genes (CD55 and CR2) in loci, which failed to reach genome-wide significance in previous AMD GWAS2,21 Interestingly, the prediction models of both genes included variants which were AMD-associated in the latest AMD GWAS but below the threshold for suggestive association (GWAS P-value < 1 × 10−04)2 (Table 2).