CASP3 and Familial prostate cancer: Lee and colleagues in 2017, reported AUR induced apoptosis through activating caspase 3 and 9 along with down regulation of anti-apoptotic Bcl2 and Mcl1, and up regulation of pro apoptotic Bax proteins in prostate cancer cells47.Our results revealed that AUR loaded PB at 15 μg.mL−1 concentration can initiate apoptosis by modulation of Bax and Bcl2 genes expression in colon carcinoma HT-29 cells more efficiently than AUR loaded TB and free AUR.