According to our bioinformatics studies in the TargetScan 7.1 and miRwalk 2.0 database, we predicted that some miRNAs, as well as miR-548x and miR-4698 could target some genes that are overactive in the PI3K/AKT pathway (PI3KCB, PI3KCA, PDK1, AKT1, Rheb, MDM2, mTOR, and CREB1) in glioblastoma. The gene discussed is RHEB; the disease is glioblastoma.