Our bioinformatics studies by Targetscan 7.1 and miRwalk 2.0 site have predicted that miR-548x and miR-4698 could simultaneously target 3ʹUTR of PI3KCB, PI3KCA, PDK1, AKT1, mTOR, MDM2, Rheb, and CREB1 genes that some of them were upregulated in glioblastoma sample according TCGA deta (Tables 1, 2). The gene discussed is CREB1; the disease is glioblastoma.