These transcriptome analyses suggested that Mafg inhibition reinstated a healthy, less inflammatory expression profile in livers of obese mice, exemplified by trends toward increased serum fibroblast growth factor 21 (FGF21) levels (Fig. 4l), a hepatokine beneficial in the context of obesity in mice50. The gene discussed is FGF21; the disease is obesity due to melanocortin 4 receptor deficiency.