Antiproliferative and pro-apoptotic synergy of IFN-γ and TNF-α have been reported in various non-Treg cell types, including colon carcinoma, neuroblastoma, salivary ductal cell lines, and pancreatic beta cells, and the specific signaling cascades are partially defined27,36–38. The gene discussed is IFNG; the disease is colon carcinoma.