This finding was confirmed by IHC-based quantification of CD8-stained tumor sections, showing a significantly higher number of intratumor lymphocytes in the ACT + NKTR-214 group compared to ACT + IL-2 group at day 14 (37.5% vs 9.3% of total tumor cells, Fig. 4a, b). This evidence concerns the gene NKTR and neoplasm.