In our study, transcriptomic profiles showed upregulation of several chemokines and their receptors in tumors of mice treated with ACT + NKTR-214, including CCL1, CCL2, CCL3, CCL4, CCL5, CCL6, CCL7, CCL8, and CXCR3, previously reported to be associated with presence of effector T cells in the tumor site24. The gene discussed is CCL5; the disease is neoplasm.