CD8A and neoplasm: Density plots of the T cell clusters showed the preferential activation of tumor-specific Thy1.1 +CD8 T cells over Tregs in spleen and tumor for the ACT + NKTR-214-treated mice, while the opposite trend was observed in the ACT + IL-2 group, both at day 7 and 14 (Fig. 4c–f, Supplementary Fig. 6b, c).