The combination of ibrutinib with either SYK inhibitor produced increased lethality in MYD88-mutated BCWM.1 and MWCL-1 WM cells, as well as MYD88/CD79B mutated TMD8 and HBL-1 ABC DLBCL cells. The gene discussed is CD79B; the disease is diffuse large B-cell lymphoma.