A cross cell line comparison of the phosphorylation levels of SYK (pY525-pY526) showed higher levels of activated SYK in MYD88-mutated versus wild-type cell lines, while ABC DLBCL cells (TMD8, HBL-1) with both MYD88 and CD79B mutations expressed higher levels of phosphorylated SYK versus MYD88 only mutated WM cells (Fig. 1a). This evidence concerns the gene MYD88 and diffuse large B-cell lymphoma.