SYK and diffuse large B-cell lymphoma: Akin to our previous findings for NFkB signaling1,5, these studies also showed that phosphorylation of SYK at Tyrosine 525 and 526 (pY525-pY526) was reduced following treatment with a MYD88 peptide inhibitor in both MYD88-mutated WM and ABC DLBCL cells (Fig. 1c).