COG2 and familial hyperaldosteronism: Our previously published work was focused on iPSC and H1 human embryonic stem cells (ESC) (collectively referred to as PSC) and the restoration of LDL-C internalization in FH iPSC using CRISPR/Cas9 (Omer et al., 2017), which is potentially important for studying the effects of statins during early development and fetal malformation (Avis et al., 2009; Kusters et al., 2012).