GRHL2 upregulates expression of the MIR141, MIR200A, MIR200B, MIR200C and MIR429 microRNAs by binding to their regulatory elements in a number of cancers (Chen et al., 2016; Chung et al., 2016; Cieply et al., 2012). The gene discussed is MIR200B; the disease is cancer.