EGFR and lung adenocarcinoma: The combination of bevacizumab and an EGFR tyrosine kinase inhibitor (TKI) robustly improved the intracranial control rate and intracranial lesion time to progression (TTP) in patients with EGFR-mutant lung adenocarcinoma, possibly by reducing the level of circulating S100A9-positive M-MDSCs, along with enhancing gene signatures associated with CD8+ T cell effector genes, Th1 chemokines, and NK cells [99].