In the four HR gene mutation cases, three of them (PDX1, PDX2, PDX3) exhibited statistically significant decrease in tumor burden when treated with Olaparib (P < 0.05 for all cases) and unsurprisingly all harbored BRCA1/2 mutation while the PDX4 who carried LIG1 mutation did not respond to Olaparib. This evidence concerns the gene LIG1 and neoplasm.