PLOD1 and polycystic ovary syndrome: The increased levels of LH in PCOS, which are due to the impaired hypothalamic-pituitary axis, stimulate PI3K/Akt pathway leading to the over expression of ovarian CYP17A1 gene together with 17-α hydroxylase enzyme levels, which catalyze the conversion of progesterone to androgens [31, 42, 43].