These pathways consisted of cytokine-cytokine receptor interaction, protein processing in endoplasmic reticulum, autoimmune thyroid disease, pyrimidine metabolism, amino sugar and nucleotide sugar metabolism, p53 signaling pathway, biosynthesis of amino acids, glycolysis / gluconeogenesis, DNA replication, proximal tubule bicarbonate reclamation, proteasome, plycine, serine and threonine metabolism, alanine, aspartate and glutamate metabolism, TNF signaling pathway, IL-17 signaling pathway, and so on. This evidence concerns the gene TNF and autoimmune thyroid disease.