In a small clinical study on AD patients with mild cognitive impairment (NCT02984540), certain gut bacteria showed significant correlation with AD CSF biomarkers (Aβ and phosphorylated tau) and further a modified Mediterranean-ketogenic diet altered gut bacterial profile [189], suggesting that such diets can regulate AD biomarkers through regulating gut microbiome and associated metabolites. Here, MAPT is linked to Cognitive impairment.