These include: a) Epi proColon, ColoVantage, Realtime mS9, all of which detect methylation in the SEPT9 gene for colon cancer detection [19]; b) Epi proLung which detects methylation of SHOX2 for lung cancer detection [20], and c) Colvera, which detects methylation at BCAT1 and IKZF1 for colon cancer recurrence [21]. The gene discussed is SHOX2; the disease is malignant colon neoplasm.