SFRP5 and obesity due to melanocortin 4 receptor deficiency: There are multiple papers focusing on the crucial roles of adipokines in constituting a critical link between the obesity, T2DM and atherosclerosis or cardiovascular diseases.11, 56, 57 SFRP5, as a novel anti‐inflammatory adipokine, might be at the crossroad between obesity, T2DM and CHD (Figure 1).