The larger dendritic spines and increased mEPSC amplitude in the TBC1D24F251L/F251L neurons in culture are noteworthy, because neurons deficient in SynGAP also possess larger spine heads and enhanced mEPSCs [52, 53] and both the SynGAP happloinsufficient mice and patients with SynGAP mutations have epilepsy [52, 54]. The gene discussed is SYNGAP1; the disease is epilepsy.