We identified 3 of 309 patients with PHTS (1.07%) and pathogenic and/or likely pathogenic CNVs affecting genes associated with PTEN-related cancers17 or other inherited cancer syndromes according to the American College of Medical Genetics and Genomics guidelines.30,31 These included 2 BMPR1A (OMIM 601299) deletions and 1 BRCA1 (OMIM 113705) deletion. Here, BMPR1A is linked to PTEN hamartoma tumor syndrome.