In summary, this study revealed that AX treatment (i) significantly ameliorated insulin resistance and glucose intolerance through regulation of AMPK activation in the muscle, independent of its antioxidant activity, (ii) stimulated mitochondrial biogenesis in the muscle, (iii) enhanced endurance and running time and exercise‐induced FA metabolism and muscle remodeling, and (iv) exerted antiinflammatory effects via its antioxidant activity in the adipose tissue. Here, PRKAA1 is linked to Insulin resistance.