CD4 and hepatocellular carcinoma: In terms of T helper (Th) cells, Endo et al performed transcriptional profiling of memory phenotype CD4 T cells in high‐fat‐fed mice and identified ACC1 as an essential regulator of Th17 cell differentiation in vitro and of the pathogenicity of Th17 cells in vivo and then pointed out that ACC1 could modulate the DNA binding of retinoic acid‐related orphan receptor gamma t (RORγt) to target genes in differentiating Th17 cells.102 However, in terms of HCC and other liver diseases, there are few studies on the lipid metabolic reprogramming of Th cells.