Hepatitis viruses, especially for hepatitis B virus (HBV) in Eastern countries and hepatitis C virus (HCV) in Western countries, are another major factor in HCC occurrence and development, which can lead to corresponding metabolic alterations.48 Typically, the HBV X protein (HBx), which is one of the four overlapping open reading frames (ORFs) in the HBV genome, is involved in the development of HBV‐associated HCC. Here, REG1A is linked to hepatocellular carcinoma.