CARS1 and hepatocellular carcinoma: In another study regarding the efficacy of sorafenib chemotherapy in HCC, Saito et al115 put forward their views that the lower levels of lipids containing FA (18:2) were related to the positive responses, whereas the lower levels of acylcarnitines (Cars) and fatty acid amides (FAAs) resulted in the susceptibility to sorafenib‐induced hand‐foot skin reaction (HFSR), which had revealed the novel candidate biomarkers.