Among them, tumour‐associated macrophages (TAMs) are the predominant M2 phenotype in solid cancers including HCC.68 Zhang et al had utilized an in vitro model to mimic the TAM‐HCC interaction in TME, and their results suggested that the M2 monocyte‐derived macrophages (MDMs) promoted HCC cell migration in an FAO‐dependent manner by enhancing IL‐1β secretion. This evidence concerns the gene IL1B and hepatocellular carcinoma.