For instance, the targeted combination of miRNA1207‐5p with FASN inhibits HCC invasion via inhibiting the Akt/mTOR signalling pathway, whereas FASN up‐regulation reverses the inhibition of miRNA‐1207‐5p on HCC cells.25, 26 Research conducted by Wu et al27 revealed a mechanism by which microRNA‐21, in part, promoted hepatic lipid accumulation and HCC tumour progression by interacting with the HBP1‐p53‐SREBP1c pathway and suggested the potential therapeutic value of microRNA‐21‐anti‐sense oligonucleotide. This evidence concerns the gene AKT1 and hepatocellular carcinoma.