In opposite, several VEGF gene SNPs acts as a decreased association or protective effect for PCOS risk: rs2010963 (Heterozygote comparison: OR = 0.68, 95% CI = 0.53–0.86, P = 0.339 for heterogeneity, P = 0.002, Figure 5, Table 2); +9812 (Allelic contrast: OR = 0.60, 95% CI = 0.43–0.83, P = 0.892 for heterogeneity, P = 0.002, Figure 3, Table 2); +405 (Homozygote comparison: OR = 0.48, 95% CI = 0.23–1.00, P = 0.327 for heterogeneity, P = 0.050, Figure 6, Table 2). The gene discussed is VEGFA; the disease is polycystic ovary syndrome.