While future research aimed at successfully targeting IL12p40 in AD implies the need to dissect its downstream mechanisms and to identify whether it is IL‐12 or IL‐23 specifically that influences AD pathogenesis, it will be equally interesting to address whether this signalling pathway also plays a gender‐specific role in other CNS proteinopathies such as Parkinson's disease or tau‐driven pathologies. Here, MAPT is linked to Alzheimer disease.