In damaged liver cells, MSC ameliorated liver fibrosis via activating autophagy,16 and human placenta‐derived mesenchymal stem cells also promoted hepatic regeneration by up‐regulating HIF‐1α and activating autophagy.44 BMSCs also attenuated lung injury by increasing the autophagy level via the PI3K/Akt signalling pathway.15 In this study, coculturing with BMSCs induced more intense autophagy than that in the hypoxia group. Here, AKT1 is linked to Hepatic fibrosis.