Since p‐ERK suppression is associated with enhanced Mcl‐1 degradation induced by Osim in sensitive EGFR‐mutant NSCLC cells, as demonstrated recently (Shi et al. 2017), we then logically asked whether the HNK and Osim combination facilitates Mcl‐1 degradation in Osim‐resistant cells. This evidence concerns the gene EGFR and non-small cell lung carcinoma.