EGFR and non-small cell lung carcinoma: We first determined the effect of Osim in the presence of HNK on the growth of different Osim ‐resistant EGFR‐mutant NSCLC cell lines including PC‐9/AR, PC‐9‐GR/AR, PC‐9/2M (19del and C797S are trans located), PC‐9/3M (19del, T790M, and C797S are cis located), HCC827/AR, and H1975/OSIR (Table 1).