PRTN3 and obesity due to melanocortin 4 receptor deficiency: One important consequence of obesity is the development of hypothalamic inflammation, which can further influence energy metabolism and the development of metabolic disturbances [29]; hence, it would be interesting to assess whether Casp1/Casp11/NE/PR3 knockout mice are protected from developing hypothalamus inflammation in obesity, which could also explain why these mice do not gain weight.