One important consequence of obesity is the development of hypothalamic inflammation, which can further influence energy metabolism and the development of metabolic disturbances [29]; hence, it would be interesting to assess whether Casp1/Casp11/NE/PR3 knockout mice are protected from developing hypothalamus inflammation in obesity, which could also explain why these mice do not gain weight. Here, SCAF11 is linked to obesity due to melanocortin 4 receptor deficiency.