PI3Kγ appears to play a role in the pathogenesis of atherosclerosis, and pharmacological inhibition of this Class I PI3K isoform with AS605240 was shown to significantly reduce early atherosclerotic lesions in Apolipoprotein E (ApoE)-null mice, and attenuate advanced atherosclerotic lesions in LDL receptor-deficient mice [170]. The gene discussed is APOE; the disease is atherosclerosis.