TRPV1 and irritable bowel syndrome: Therefore, in order to improve the potential application of TRPV1-related signaling in the therapy of IBS, capsaicin derivatives (i.e., olvanil (N-oleoyl-vanillamine), arvanil N-arachidonoyl-vanillamine, or palvanil (N-palmitoyl-vanillamine) deprived of pungent effect with ability to fast TRPV1 desensitization are considered a promising alternative to capsaicin (Luongo et al. 2012; De Petrocellis et al. 2011; Ursu et al. 2010).