PXA is an uncommon glial neoplasm; its classic features include location in the superficial temporal lobe, lipid-laden xanthomatous cells, and marked nuclear atypia, including multinucleated cells.1 Most PXAs are driven by BRAF V600E mutation,2 making it part of the family of brain tumors characterized by MAPK activation. The gene discussed is BRAF; the disease is brain neoplasm.