SETD2 and central nervous system cancer: Along with BRAF V600E mutation, the original temporal lobe tumor had mutations in the TERT promoter and SETD2; the latter encodes a histone lysine methyltransferase and has been found most often in high-grade gliomas arising in children and young adults.9,10 Even though the original tumor did not appear to be high grade, and the chest wall tumor did not resemble the original tumor, they had the exact same mutations (plus a TP53 mutation in the chest wall tumor).