TGF-β is one of the important factors in stem cells differentiation into chondrocyte, causing enhancement of theCOL2A1, ACAN genes expression.43 This factor has a short half-life about three days and for more efficiency should be used freshly.44 Due to the increase in osteoarthritis in the world and the significant role that nutrition plays in the metabolism of chondrocytes, researchers use plant compounds for differentiation of stem cells into chondrocytes. The gene discussed is ACAN; the disease is osteoarthritis.