Their results showed that Sirt1 gene was upregulated in the normal and osteoarthritis chondrocytes treated with 25 and 50 μM of Res at 72 hours.48 Therefore, the results of various studies indicated that the expression of the Sirt1 gene depends on the cell type, type of used substance and the duration of incubation. Here, SIRT1 is linked to osteoarthritis.