Although these results were obtained in a small series of patients, the results are in line with previous studies indicating a link between ISG expression and presence of TILs in melanomas.4,23 When comparing receptor expression on TILs and PBMCs, the TILs showed higher expression of CCR5 and PD-1 but tended to express lower levels of CXCR3 and CCR4. The gene discussed is PDCD1; the disease is melanoma.