We have previously reported that circulating CD8+ T cells become activated following ILP and that the presence of activated CD8+ T cells in blood predicts complete disappearance of tumors in the perfused area.13,14,21 For the present study, we assessed the potential role of ISG-associated chemokines, chemokine receptors and related mediators for the benefit of ILP in patients with in-transit metastatic melanoma. The gene discussed is XIAP; the disease is metastatic melanoma.