CXCR3 and melanoma: CXCR3 has been ascribed a dual role in melanoma as its expression on lymphocytes may facilitate the recruitment of T cells and NK cells to the tumor microenvironment, but expression of CXCR3 on melanoma cells themselves may enhance metastatic spread.8,9,25 As we did not have access to tumor biopsies after ILP, in vivo effects of melphalan on CXCR3 expression on melanoma cells were not investigated.