TNFAIP3 and blood coagulation disease: In addition to modifications targeting coagulation disorders in xenotransplantation, transgenic pigs expressing antiapoptotic and antiinflammatory proteins, such as human tumor necrosis factor-alpha-induced protein 3 (A20) (Oropeza et al., 2009) and human heme oxygenase-1 (HO-1) (Petersen et al., 2011), have been produced.