Reduction in tumor size and delay in tumor growth by rATRAM-GRA8-M/AS was dependent on PKCα, SIRT3, ATP5A1 (Figure 4C–4E and Supplementary Figure 3A), and the acetylation status of ATPA1 K506 and K531 (Figure 4F and Supplementary Figure 3B) in the HCT116 colon-cancer xenograft model. This evidence concerns the gene SIRT3 and malignant colon neoplasm.