VDAC1 and cancer: In cancer cells, upon AKT activation, HKII translocates to the outer mitochondrial membrane and binds to VDAC, which interacts with ANT of the inner-mitochondrial membrane, and so preferentially accesses ATP produced by mitochondrial oxidative phosphorylation and phosphorylates glucose to produce glucose 6-phosphate, mediating the first step of glycolysis.